SYNCHRO START
Injectable products based on a buffered saline solution of hyaluronic acid sodium salt (respectively at 0.8% and 1.6%), with notable viscoelastic properties, highly purified, with a molecular weight between 800 and 1,200 kDaltons.
Sodium hyaluronate is a fundamental component of synovial fluid, responsible for its particular viscoelastic properties.
The sodium hyaluronate of SYNCHRO is obtained through fermentation, excluding any chemical modification treatment, to ensure an absolutely pure product free of residues foreign to the physiological context of use.
The packages include a single-use glass syringe pre-filled with 2 ml of sterile and pyrogen-free solution.
In traumatic and degenerative joint diseases, a decrease in hyaluronic acid in situ is observed, with a consequent reduction in synovial fluid viscosity. This deficiency causes a compromise in joint functionality and painful symptoms. The administration of hyaluronic acid intra-articularly can restore the viscoelastic properties of the synovial fluid, with a clear improvement in joint mobility and consequent pain relief and anti-inflammatory response.
The recommended SYNCHRO protocol involves a two-stage intervention: the first consists of 2 treatments at a weekly interval, performed with SYNCHRO Start 1.6%, aiming to favorably condition the joint compartment through an impactful action, reducing symptoms and maintaining prolonged in situ presence (due to higher concentration). Subsequent infiltrations (3 treatments at a weekly interval), performed with SYNCHRO Basic 0.8%, will serve to maintain and stabilize.
SYNCHRO has excellent tolerability, acting only locally (in the joint compartment where it is injected), excluding any systemic actions.
Clinical tests demonstrate that SYNCHRO results in a general improvement of the affected area, with a reduction in pain and swelling and a functional recovery of the joint. These benefits can last up to 24 weeks.
Directions for use
Inject 2 ml of product intra-articularly once a week for 3 weeks, unless otherwise instructed by the doctor and according to the patient’s condition. If additional treatment cycles are necessary, it is recommended to observe an interval of 6 months. At the doctor’s discretion, based on the patient’s health condition, it is possible to treat multiple joints simultaneously.
Aspirate any joint effusion before proceeding with the injection of SYNCHRO Basic or SYNCHRO Start. Remove the cap from the syringe carefully to avoid contact with the opening. Insert an appropriate size needle (from 18 to 22 G) and screw it tightly to ensure a watertight seal and prevent solution leakage. Inject the device only inside the synovial space, at room temperature and under appropriate conditions.
Components
Sodium hyaluronate. Other components: sodium chloride, phosphate buffer, water for injectable solutions.
Warnings
Do not use after the expiry date printed on the packaging. Do not use if the package is open or damaged.
The area where the injection is performed must be on healthy skin.
Do not inject via the vascular route.
Do not inject into the knee joint in the presence of venous or lymphatic stasis of the limb.
Do not inject outside the joint cavity, into synovial tissue or joint capsule.
Do not administer in the presence of severe intra-articular effusions.
SYNCHRO Start and SYNCHRO Basic should not be injected in the presence of infections, inflammations, or skin conditions in the area to be treated.
After intra-articular injection, it is recommended for the patient to avoid all intense physical activities and to resume normal activities only after a few days.
The contents of the pre-filled syringe are sterile.
The outer surface of the syringe is not sterile.
Do not sterilize again. The device is single-use.
Once opened, the device must be used immediately and discarded after use.
Keep out of reach of children.
Storage
Store at a temperature below 25°C and away from heat sources. Do not freeze.
Format
Pack of 1 pre-filled single-use syringe (32.0 mg of hyaluronic acid sodium salt in 2 g of buffered saline solution). Sterilized by moist heat.
Code SY700
